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Depression and anxiety in inflammatory bowel disease: epidemiology, mechanisms and treatment

Clinical trials have not consistently shown improvement in cognitive function among older adults with or without dementia when supplemented with vitamin B12 alone or in combination with other B vitamins, even when blood concentrations of homocysteine come down

TF exists in three isoforms: full-length TF (as described above), an alternatively spliced TF (asTF) isoform generated by the omission of exon 5 during processing of the TF primary transcript, which causes a frameshift

Once CXXC5 suppression is fully addressed, additional improvement requires targeting other mechanisms through complementary treatments