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Shults EE, Shakirov MM, Pokrovsky MA, Petrova TN, Pokrovsky AG, Gorovoy PG

This is why calcium channel blockers are commonly used for high blood pressure

doi: 10.1126/science.abd0811 65 BrueyJMBruey-SedanoNLucianoFZhaiDBalpaiRXuCet al

Wait at least 72 hours, then reintroduce slowly rather than at full strength, because retinoids thin the stratum corneum and raise sensitivity, so starting too early stacks irritation on a barrier that is still rebuilding