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Thus we still have to be aware of the potential limitations as well as we have to bear in mind that the apparent diagnostic performance of a biomarker depends not only on its ability to detect injury, but also on disease prevalence and the sensitivity and specificity of the imperfect gold standard 25

Over time, the skin in this area loses its firmness, resulting in drooping skin and tissue along the lower face

Additionally, GLP-1 agonists slow gastric emptying, meaning food remains in the stomach longer, which prolongs satiety after meals and reduces the frequency of hunger signals