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The dominant Cu uptake pathway in each situation may depend on the expression of the respective transporter

Mild skin irritation (redness, burning sensation) when using high concentrations

The cases that end up in the operating room are the ones where conservative management wasn't started in time, wasn't followed consistently, or where the deformity has already progressed beyond what a cast and footwear can address

In our group, we have demonstrated that low doses of IGF-I restored circulating IGF-I levels, which improves insulin resistance and lipid metabolism in aging rats[55], thus becoming a potential beneficial agent to prevent insulin resistance-related pathologies