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In clinical practice, multiple studies have confirmed that chemotherapy drugs increasing cytokine production such as TNF-, Monocyte chemoattractant protein-1 (MCP-1), Interleukin 10 (IL-10), IL-6, and Interleukin 8 (IL-8) in cancer patients and this phenomenon is more prominent in patients who experienced dyscognition (Tsavaris et al., 2002

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Selectively increased necrosis in these xenografts