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Also, the production of E-selectin, ICAM-1, IL-8, and MCP-1, evaluated in the cell culture supernatants, as well as the generation of ROS and malondialdehyde, in HUVECs, significantly increased with arsenic treatment [188]

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In addition, H2O2 is involved in mediating biological processes, including PCD (Desikan et al., 1998), ABA-mediated stomatal closure (Pei et al., 2000), auxin-regulated gravitropic responses (Joo et al., 2001), mechanical wounding response (Orozco-Cardenas et al., 2001), systematically acquired resistance (SAR) (Inz and Van Montagu, 1995), plant pathogen interaction (Mittler et al., 1999), and some other processes relating to both biotic and abiotic stresses (Desikan et al., 2003)

Glutathione as an Antioxidant An antioxidant is broadly defined as anything that neutralizes oxidantsoften used interchangeably with free radicals