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With respect to VHE, Verrotti and coworkers [69] demonstrated an increase in glutamine production in astrocytes whereas glutamine release was inhibited

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Still, some early clinical findings hint at potential uses in more specific contexts: Perioperative brain protection: A randomized controlled trial involving 155 liver surgery patients found that ALA reduced oxidative brain injury from anesthesia (sevoflurane) and improved cognitive recovery scores after surgery.31 Neurodegenerative conditions: In a small trial, ALA appeared to slow brain atrophy in patients with secondary progressive multiple sclerosis over a two-year period.32 While promising, this outcome still needs further confirmation

179 In preclinical research, alpha-casozepine, a 10-amino acid peptide derived from casein tryptic hydrolysate, has been found to sensitize GABA receptors and relieve anxiety related to stress without triggering dependence