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This flexibility is especially important in outbreak settings, where speed of reformulation can strongly influence public health responsiveness [216]

In 2017, the manufacturer of Euthyrox (a brand of levothyroxine) reformulated the medication to improve its stability

Ramesh, G

However, simulations can be sensitive to force field settings and are difficult to replicate under real-life conditions, limiting their clinical translation potential ( in vivo and in vitro experiments are still needed (Figure 1)