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Increasing levels of SOD or GR can alleviate oxidative stress of intervertebral disc tissue and help treat IDD at this point

[DOI] [PubMed] [Google Scholar] 49.De Petrocellis L., Vellani V., Schiano-Moriello A., Marini P., Magherini P.C., Orlando P., Di Marzo V

10.1371/journal.pone.0211837 136

Moreover, Cr competitively binds the active site of cellular prion protein, inhibiting the conversion of Fe 3+ to Fe 2+ and reducing cellular iron uptake