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36 FeuerL.S.-RzsaK

Xiong Z, Guo M, Yu Y, Zhang FF, Ge MK, Chen GQ, et al

MOTS-c activates AMPK (AMP-activated protein kinase), which signals cells to shift from glucose storage to fat oxidation and improves insulin sensitivity through mitochondrial and nuclear gene regulation

In calves, Sertoli cells, Se improved cell viability and expression of bloodtestis-barrier proteins (occludin, connexin-43, zonula occluden, E-cadherin) by modulating the expression of mitochondria-related genes, inhibiting the nuclear factor kappa B (NFB) activation of inflammatory cytokines and apoptosis, and increasing the GPX4 activity (160, 161)