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The FAM171A2 gene is a key regulator of progranulin expression and modifies the risk of multiple neurodegenerative diseases

Rather, mutations affecting the dimerization interfaces of the G6PD protein and in proximity to the NADP + binding site may cause more detrimental effects compared to mutations of residues in other less conserved sites

Isothiocyanates have been shown to prevent the formation of capillary-like structures from human umbilical endothelial cells (reviewed in 35)

Moreover, it was unclear at the time which cellular phenotypes correspond to either primary or secondary effects due to the lack of FXN