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On 3D EM, mitochondrial cristae spacing was less with ET and consistently, on RNAseq, cristae formation geneset showed significant alterations ( Fig1C )

Vegetarians and vegans, since B12 is primarily found in animal-based foods, may experience a deficiency that can become significant over time

This disconnect between in vivo and human studies might be due to the different sample characteristics, inter-individual variabilities related to past history of drug use, consumption rate, psychological problems, and differences in the experimental methodology (Matochik et al., 2005

Cox M, Klutke JJ and Klutke CG: Assessment of patient outcomes following submucosal injection of triamcinolone for treatment of hunner's ulcer subtype interstitial cystitis