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As Kraus et al

In this study, we demonstrate that cells harboring the Tibetan-specific M9a haplogroup with downregulated EPAS1 (M9a+sh EPAS1 ) exhibit enhanced cellular function under hypoxic conditions

This observation was further confirmed by repeating the Cp1A assay with succinic acid- d 4 , which showed the incorporation of deuterium atoms into 3-NPH-fumaric acid (Supplementary Fig