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In contrast, Nrf2 activators, such as sulforaphane, have been found to prevent homocysteine- or hydrogen peroxide-induced cataract formation in human lens epithelial cells by increasing nuclear translocation of Nrf2 and expressions of cellular antioxidants, including catalase, superoxide dismutase, glutathione peroxidase, and glutathione

A comprehensive review found that phosphodiesterase-5 inhibitors alone effectively treat lower urinary tract symptoms and erectile dysfunction, and that treatment with both phosphodiesterase-5 inhibitors and alpha-blockers leads to a small improvement in flow rates in men with BPH

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10.3389/fmolb.2021.793732 46 JiangY.ZhaoJ.LiR.LiuY.ZhouL.WangC.et al (2022b)