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Dually phosphorylated PPPSPxS motifs (designated PPPpSPxpS) act synergistically and interchangeably to inhibit GSK3 in Wnt-stimulated cells 33 , however only the phosphorylation at P + 4 is essential for Wnt signal transduction while that at P + 7 is merely contributory 25

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SALL2 activity could be restored using DNA methyltransferase (DNMT), therefore co-administration of tamoxifen and DNMT inhibitors like 5-Aza-20-deoxycytidine (5-Aza-dC), is a rational approach to re-sensitize patients tamoxifen resistant breast cancer patients [58]