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The ablation of OPLAH in mouse models has led to an accumulation of 5-OP, which results in oxidative stress, fibrosis, and the continued elevation of pressure due to heart failure [125]

The deviation of the sigmoid curve fit, found after the T50 is reached, suggested the presence of a subpopulation of cells, better equipped to withstand oxidative stress, or a different distribution in the heterogeneous population as shown in Fig