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Fife patients died 1, 3, 3 and 6 months after GC+D treatment initiation due to thrombosis (n=1) or cholangitis (n=4), all of which were ECOG 1 or 2 at treatment initiation

ROS-producing enzymes involved in increased oxidative stress within vascular tissues include the NADPH oxidase (Nox), the xanthine oxidase and the mitochondrial respiratory chain