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In a 2003 in vitro experiment by Khavinson and colleagues, addition of micromolar concentrations of the peptide to cultured human somatic fibroblasts produced a measurable increase in telomerase reverse transcriptase activity and a corresponding extension of telomere length across 1020 passages, with cell cultures continuing to divide beyond the Hayflick limit observed in untreated controls

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and autonomic airway fibers innervating airway muscles, blood vessels and lungs (substance P (SP), neurokinin A (NKA) and vasoactive intestinal polypeptide (VIP)) [5]