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Description

Multifunctional (99m)Tc-5-azacitidine gold nanoparticles: formulation, in vitro cytotoxicity, radiosynthesis, and in vivo pharmacokinetic study

Early nano-delivery systems such as liposomes and nanosuspensions initially suffered from storage instability (e.g., payload leakage and particle aggregation), but subsequent formulation optimization has greatly improved their robustness and yielded storage-stable products at scale (187, 188)