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recently found that when GPX4 was inactivated, FSP1 could maintain the growth of lung cancer cells, which implied that FSP1 contributed to the resistance against cell ferroptosis and might be one important drug target for cancer treatment ( Nrf2 Nrf2 is an important regulator of cellular antioxidant responses ( Studies have reported that Nrf2 can transcriptionally regulate the expression of a series of downstream genes related to ferroptosis, including NAD(P)H:quinone oxidoreductase 1, HO-1, SLC7A11, and GPX4 (Tian et al., 2022)