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10.1002/cctc.201700665 27 GongJ

Nrf2, a transcription factor that is highly responsive to oxidative stress, serves a key role in mitigating lipid peroxidation and ferroptosis (62)

Microglia-specific TRPM2 deletion led to reduced expression of Iba-1 and GFAP, as well as lower mRNA levels of pro-inflammatory cytokines IL-1, IL-6, and TNF- in both the latent (3 days post-injection) and chronic (5 weeks post-injection) phases