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Mol Metab 2014;3:507-17.ArticlePubMedPMC 23

K.LindingerM

The more conserved (i.e., non-hypervariable) portions of the variable domains are called the "framework" regions (FRM or FR) and provide a scaffold for the six CDRs in three dimensional space to form an antigen-binding surface

While preclinical studies demonstrated promising effects in animal models of PD, clinical translation remains challenging due to ethical, logistical, and biological constraints