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Regulation of Fatty Acid Synthesis Fatty acid synthesis is tightly regulated at multiple levels: Hormonal regulation : Insulin stimulates, glucagon inhibits Allosteric regulation : Citrate activates ACC Feedback inhibition : Long-chain fatty acids inhibit ACC Reciprocal regulation with -oxidation via malonyl-CoA Malonyl-CoA serves a dual purpose: it is the building block for fat synthesis, AND it is a potent inhibitor of CPT-1

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High-density lipoprotein (HDL) is called good cholesterol because it returns cholesterol back to the liver for removal

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