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Sustained improvement is unlikely if exposure continues

For instance, the secretion of interferon gamma (IFN-) by CD8+ T cells has been shown to down-regulate the expression of SLC3A2 and SLC7A11 in tumor cells, leading to a disruption in cystine uptake ( Myeloid-derived suppressor cells (MDSCs) express the transporter SLC7A11, which selectively transports cystathionine but does not export cysteine

Still, the favorable risk/benefit ratio justifies continuing the use of silymarin in these indications