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Epstein-Barr virus latent membrane protein-1 (LMP1) signalling is distinct from CD40 and involves physical cooperation of its two C-terminus functional regions

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Thus, by activating the coagulationinflammation axis, worsening the local microenvironment, promoting urate crystal aggregation, and accelerating tissue fibrosis, hypercoagulability contributes significantly to tophus development and persistence