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Tarangelo et al., 2018

doi: 10.1016/j.nbd.2022.105649 54 HbnerCHaaseH

Dose-response relationships: Biological effects show threshold (minimum effective concentration), linear response zone (increasing dose produces proportional benefits), and saturation (maximum benefit reached, further increases provide minimal additional effect)

Following IM administration of atropine in one study, elimination of the drug (determined by urinary excretion of radiolabeled drug) appeared to be biphasic, with a half-life in the initial phase of about 2 hours and a half-life in the terminal phase of 12.5 hours or longer