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Alcohols bladder-irritating and dehydrating effects are most counterproductive during this recovery window

Circulation 119 , 12721283 (2009)

In order to get rid of contaminating metal ions in the buffer, the mobile phase was eluted through the Chelex100 Chelating Ion Exchange resin (Sigma, Merck KGaA, Darmstadt, Germany) prior to liquid chromatographic separation

Approaches like these will enable the field to evaluate early signals of clinical efficacy and build a roadmap for predicting clinical effects, all of which requires greater understanding of both disease and treatment effects on specific neural circuits