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In parallel, mitochondria influence nuclear epigenetic regulation by generating metabolic intermediates and cofactors, encompassing acetyl-CoA, NAD+, S-adenosylmethionine (SAM), and -ketoglutarate (-KG)which function as substrates for chromatin-modifying enzyme [4]

10.1111/nyas.13519 Ann N Y Acad Sci

Macrophage immunometabolism dysregulation and inflammatory disorders

(2010) demonstrated that selenoproteins are indispensable in skin development by knocking out the selenocysteine tRNA gene in keratin14-expressing cells, which generated mice with epidermal hyperplasia and abnormal hair follicle development