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These metabolites are produced by the gut microbiota upon the absorption of specific substances and function as signaling molecules and reaction substrates during metabolic processes, playing a crucial role in the onset and progression of lung diseases, including lung infections

CD47 is upregulated on circulating hematopoietic stem cells and leukemia cells to avoid phagocytosis

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Although the MISEV guidelines have improved transparency and rigor in EV reporting, they primarily address minimal reporting standards and do not yet resolve critical issues related to inter- and intra-batch heterogeneity, potency assessment, or clinical-grade validation (MISEV guidelines