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doi: 10.1016/j.tifs.2020.03.018 64

The only study with negative results reported that did not attenuate disease progression with possible negative effects on skeletal muscle (observed by functionality, voluntary muscle activation and cross-sectional area), with loss of muscle strength and power (Jensen et al., 2017)

Western blot analysis of tumor tissues collected after three days of treatment revealed marked KRAS G12C degradation, confirming in vivo target engagement (Fig