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Growth hormone (GH) deprivation induced by passive immunization against rat GH-releasing factor delays sexual maturation in the male rat

[DOI] [PubMed] [Google Scholar] 57.Ren H, Wang Z, Li Y, Liu J

The effects can last for 4 to 6 hours, but individual response times may differ

That is generally described as a more physiologic pattern than the pharmacologic square-wave of exogenous HGH, and it is one reason secretagogues were pursued as candidate tools to enhance GH secretion in disease and aging in the first place