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10.1371/journal.pone.0026064 PLoS One 10 BallanyiK

Hepatic metabolism of alcohol yields acetaldehyde, but further degradation in the oxidatively stressed mitochondria is compromised with symptoms ranging from headache to hangover, both acetaldehyde induced

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Physical methods to induce degeneration have included protocols such as forelimb amputations to force bipedalism, annulotomies, and endplate injury (Yamada, 1962