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Elevated calcium and ROS levels are known to be potent triggers for mitochondrial permeability transition pore (mPTP) opening, leading to mitochondrial swelling and cytochrome C release, subsequently, activating cell apoptosis cascade (Figure 1

doi: 10.1016/j.ymthe.2023.10.016 102 LiuYHuangKZhouSLLiSSiHBZengYet al

ATO first binds to specific cysteine residues within the PML moiety of the fusion protein

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