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Vitamin B12deficiency can manifest itself in the following clinical pictures: Hyperchromic macrocytic megaloblastic anemia (perniciosa, Biermer anemia, Addison's anemia these are disorders of the maturation of red blood cells) Funicular spinal disease [damage to the spinal cord] A vitamin B12deficiencyconfirmed by laboratorydiagnosis can occur in: Years of malnutrition and malnutrition (e.g through strict vegetarian diet)

alkyl may include methyl, ethyl, propyl, isopropyl, butyl, t-butyl, isobutyl, pentyl, hexyl, isohexyl, heptyl, 4,4-dimethylpentyl, octyl, 2,2,4-trimethylpentyl, nonyl, decyl, undecyl, and dodecyl

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2e, f, 6a), while the conserved His108 ( Sas Pcob numbering) provides the lower axial ligand to the Co atom of the B 12 cofactor (i.e., base-off His-on ligation, Fig