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When NNMT activity is dialed down, it allows for increased levels of nicotinamide adenine dinucleotide (NAD+), a coenzyme absolutely critical for countless metabolic processes, including energy production and cellular repair

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For a 100kg person, that translates to approximately 22.5kg (49.5 pounds) over 18 months

Additionally, increased SAM availability supports methylation reactions essential for epigenetic regulation and polyamine synthesis, influencing cellular differentiation and metabolic programming