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J Neurosci 38:75057515

Cell culture systems are essential across drug discovery, vaccine production, regenerative medicine, tissue engineering, diagnostics, and biopharmaceutical manufacturing workflows

Thus, in the presence of significant cellular damage, a decrease in the biosynthesis of ACh in the rats brain could lead to a downward modulation of AChE since its activity level directly depends on the presence of ACh at post-synaptic receptors (Ben Saad et al., 2017)