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The importance of nonaxonal pressure targets was accentuated in a landmark study by Morgans group, which demonstrated that pressure-induced dendritic retraction and RGC loss occur in the presence of intact axons (62)

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UCP2 inhibition in ALS motor neurons alters bioenergetics but does not impact the redox status Previous investigations linked the uncoupling protein 2 (UCP2) to mitochondrial dysfunction in ALS 3,31,32 , so we tested the role of this protein in the bioenergetic alterations of ALS mice motor neurons observed in our study