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Clin Trials J 1988;25:227-237

Tertiary AD differs in that patients may experience a mix of Cushingoid appearance and AD symptoms

They found that levels were significantly decreased in these patients, as compared to age-matched individuals without depression

However, due to its mechanism of blocking VLDL lipidation and secretion, which can cause hepatic TG accumulation, the Federal Drug Administration (FDA) issued a black box warning for hepatotoxicity, and the European Medicines Agency (EMA) did not approve use of mipomersen