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doi: 10.1126/science.1194637 65 GonzlezM.RojasS.AvilaP.CabreraL.VillalobosR.PalmaC.et al

Metabolism Alprazolam is extensively metabolized in humans, primarily by cytochrome P450 3A4 (CYP3A4), to 2 major active metabolites in the plasma: 4-hydroxyalprazolam and -hydroxy alprazolam