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3.2.5 LRRK2 The leucine-rich repeat kinase 2 (LRRK2) participates in mitochondrial dynamics, oxidative stress, and lipid metabolism (160)

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(K/H)DEL SIGNAL An ER-localization motif for soluble lumenal proteins that includes the short carboxy-terminal sequence Lys/His-Asp-Glu-Leu

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Clinical severity was graded as 0 (normal), 0.5 (erythema and edema in only one digit), 1 (erythema and mild edema of the footpad, or ankle or two to five digits), 2 (erythema and moderate edema of two joints [footpad or ankle, two to five digits]), 3 (erythema and severe edema of the entire paw), or 4 (reduced swelling and deformation leading to incapacitated limb) 68

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