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Description

Continuous stimulation can downregulate receptors over time, reducing effectiveness

That is a real risk arguably a greater one than the theoretical risks the FDA cited when it enacted the 2023 restrictions

There is a need for greater transparency and alignment in how weight management RCTs are designed, conducted, and reported to help different stakeholders (e.g., clinicians, regulatory bodies, prescribers, patients, payers, and guideline developers) understand how estimated treatment effects should be interpreted