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In addition, emerging evidence implicates ferroptosis functions in rheumatoid arthritis (RA) and osteosarcoma pathogenesis, both of which can manifest clinically as significant bone pain (116, 117)

Cortical tissue was dissected, digested with 0.75 mg/ml collagenase at 37 C for 30 min, and digestion was terminated using DMEM/F12 containing 10% FBS

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