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10.1371/journal.pone.0043304 [DOI] [PMC free article] [PubMed] [Google Scholar] 76.DeTure MA, Dickson DW

Montestrucq L

All graphs show the mean + standard deviation (SD) or mean + standard error of the mean (SEM), as indicated in the legends

Results Disruption of the glucagon receptor significantly alters both gene expression and the interactive network of cells To comprehensively examine the functional and physiological changes in cells following GCGR blockade, we conducted single-cell RNA sequencing (scRNA-seq) on islets isolated from 1214-week-old male wild-type (WT) and GCGR-knockout (KO) mice (Fig