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All authors have made a significant contribution to this study and have approved the final manuscript

The antidepressant mechanism of Hypericum perforatum

After ingestion, the aglycone moiety of glycyrrhizin is hydrolyzed by glucuronidase to form two stereoisomers, 18-glycyrrhetinic acid (18-GA) and 18-glycyrrhetinic acid (18-GA), which differ only in the configuration of the C18-H group (Chen et al., 2020)