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This difference is due to absorption of drug from the patch directly into the systemic circulatory system, while orally administered preparations are absorbed into the gastrointestinal and portal circulatory system and exposed to first-pass metabolism before entry into the systemic circulatory system and becoming available in the central nervous system (Figure 2).47 Subsequently, STS results in higher and more sustained steady-state levels of selegiline compared with the oral formulation

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Based on these two studies, and despite the inability to determine whether the decline in RA activity and improvement of blood lipid status were the result of specific dietary ingredients or probiotics, it was concluded that the combination of probiotics and anti-inflammatory foods might have synergistic effects, providing potential reference significance for formulating a daily dietary strategy for patients with RA