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& Azevedo, H

Genetic depletion of COX-1 could significantly attenuate diabetic hypertension in mice, which is related to decreased endothelial PGI2 synthesis and the resultant amelioration of vasoconstrictor activity under this pathological condition

360 Disulfide formation in proteins is reversible, as two cysteine thiols are oxidized into a linked disulfide via thiol-disulfide exchange or oxygen-dependent reactions, often requiring catalysts such as transition metals or flavin adenine dinucleotide (FAD) due to kinetic barriers