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Glutathione depletion, especially in the liver, commonly occurs as a side eect of the use of opioids for anesthesia and during drug abuse, resulting in the accumulation of reactive oxygen species and concomitant liver and kidney damage

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Another NAM analog-based NNMT inhibitor, 6-methoxy NAM (also known as JBSNF000088), has shown promise in decreasing body weight and enhancing insulin sensitivity in mice models of obesity induced by a high-fat diet 198

Clinicians categorize pain into four basic types: acute/nociceptive, chronic, and neuropathic (2)(22)