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Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species

10.1126/scitranslmed.abj0716 Summary Keywords Pseudomonas aeruginosa , antibiotic resistance, biosynthesis of fatty acids, ciprofloxacin, membrane permeability, metabolomics Citation Su Y, Tang X, Zhu L, Yang K, Pan L, Li H and Chen Z (2022) Enhanced Biosynthesis of Fatty Acids Contributes to Ciprofloxacin Resistance in Pseudomonas aeruginosa

This pathway enhances the secretion of fibrogenic and inflammatory cytokines, particularly TGF-1, exacerbating matrix deposition, promoting liver stiffness, and impairing immune cell functionhallmarks of fibrotic progression toward HCC [81, 128]