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Manganese-induced neurotoxicity: New insights into the triad of protein misfolding, mitochondrial impairment, and neuroinflammation

Unlike other forms of cell death, ICD is triggered by a narrow range of stimuli, including chemotherapy agents, viral infections, and various physical or chemical factors

Molecules such as hydrogen peroxide (H 2 O 2 ), singlet oxygen, and hydroxyl radicals are highly reactive with numerous biological targets and play crucial roles in neuromodulation, immunomodulation, ion transport, and apoptosis (Mittler, 2017)