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Macrophage studies demonstrate that GHK-Cu administration shifts these cells from a pro-inflammatory M1 phenotype to a tissue-repairing M2 phenotype, increasing their production of growth factors including vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) by 40-60%

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That depth of evidence gives us substantially more confidence in its mechanisms and effects than we can have with newer, less-studied compounds

Pickart couldnt have predicted the gene expression data when he was watching liver cells in 1973